Movement Disorders

Authors Flores-León M, Outeiro TF Journal Movement Disorders Citation Mov Disord. 2025 Dec 26. Abstract Neurodegenerative diseases are pathological states characterized by progressive alterations in brain homeostasis during aging. Synucleinopathies, including Parkinson’s disease and dementia with Lewy bodies, are defined neuropathologically by the accumulation of inclusions known as Lewy bodies

Authors Outeiro TF, Koss DJ Journal Movement Disorders Citation Mov Disord. 2025 Nov 26. Abstract Alpha-synuclein (aSyn), historically studied for its synaptic functions and central role in Lewy body pathology, is emerging as a protein with significant nuclear activities relevant to Parkinson’s disease (PD) and related synucleinopathies. Recent advances reveal

Authors Al-Azzani M, Weber S, Ramalingam N, Ramón M, Shvachiy L, Mestre G, Zech M, Sicking K, de Opakua AI, Jayanthi V, Amaral L, Agarwal A, Chandran A, Chaves SR, Winkelmann J, Trenkwalder C, Schwager M, Pauli S, Dettmer U, Fernández CO, Lautenschläger J, Zweckstetter M, Busnadiego RF, Mollenhauer B,

Authors Outeiro TF, Kalia LV, Bezard E, Ferrario J, Lin CH, Salama M, Standaert DG, Taiwo L, Takahashi R, Vila M, Mollenhauer B, Svenningsson P; MDS Journal Movement Disorders Citation Mov Disord. 2024 Apr 4. Abstract Basic Science is crucial for the advancement of clinical care for Movement Disorders. Here,

Authors Outeiro TF, Alcalay RN, Antonini A, Attems J, Bonifati V, Cardoso F, Chesselet MF, Hardy J, Madeo G, McKeith I, Mollenhauer B, Moore DJ, Rascol O, Schlossmacher MG, Soreq H, Stefanis L, Ferreira JJ Journal Movement Disorders Citation Mov Disord. 2023 May 8. Abstract Background: More than 200 years

Authors Thom T, Schmitz M, Fischer AL, Correia A, Correia S, Llorens F, Pique AV, Möbius W, Domingues R, Zafar S, Stoops E, Silva CJ, Fischer A, Outeiro TF, Zerr I Journal Movement Disorders Citation Mov Disord. 2021 Aug 27. Abstract Background The cellular prion protein (PrPC) is a membrane-bound,

Authors Stuendl A, Kraus T, Chatterjee M, Zapke B, Sadowski B, Moebius W, Hobert MA, Deuschle C, Brockmann K, Maetzler W, Mollenhauer B, Schneider A Journal Movement Disorders Citation Mov Disord. 2021 May 18. Abstract Background: Extracellular vesicles are small vesicles that are released from many cells, including neurons. α-Synuclein

Authors Koss DJ, Campesan S, Giorgini F, Outeiro TF Journal Movement Disorders Citation Mov Disord. 2021 May 3. Abstract Intracellular vesicular trafficking is essential for neuronal development, function, and homeostasis and serves to process, direct, and sort proteins, lipids, and other cargo throughout the cell. This intricate system of membrane

Authors Filippou PS, Outeiro TF Journal Movement Disorders Citation Mov Disord. 2020 Dec 21. Abstract Cancer and neurodegeneration are two major leading causes of morbidity and death worldwide. At first sight, the two fields do not seem to share much in common and, if anything, might be placed on opposite

Authors Outeiro TF, Heutink P, Bezard E, Cenci AM Journal Movement Disorders Citation Mov Disord. 2020 Nov 16. Abstract Parkinson’s disease (PD) is primarily known as a movement disorder because of typical clinical manifestations associated with the loss of dopaminergic neurons in the substantia nigra. However, it is now widely