Molecular Cell

Authors Rouvière JO, Salerno-Kochan A, Lykke-Andersen S, Garland W, Dou Y, Rathore O, Smidova Molska E, Wu G, Schmid M, Bugai A, Jakobsen L, Zumer K, Cramer P, Andersen JS, Conti E, Jensen TH Journal Molecular Cell Citation Mol Cell. 2023 Jul 6;83(13):2240-2257.e6. Abstract The RNA-binding ARS2 protein is centrally

Authors Garg G, Dienemann C, Farnung L, Schwarz J, Linden A, Urlaub H, Cramer P Journal Molecular Cell Citation Mol Cell 2023. in press. Abstract Co-transcriptional capping of the nascent pre-mRNA 5′ end prevents degradation of RNA polymerase (Pol) II transcripts and suppresses the innate immune response. Here, we provide

Authors Ulrich K, Farkas Á, Chan O, Katamanin O, Schwappach B, Jakob U Journal Molecular Cell Citation Mol Cell. 2022 Sep 1;82(17):3226-3238.e7. Abstract Oxidative stress conditions can cause ATP depletion, oxidative protein unfolding, and potentially toxic protein aggregation. To alleviate this proteotoxic stress, the highly conserved yeast protein, Get3, switches

Authors Farnung L, Ochmann M, Garg G, Vos SM, Cramer P Journal Molecular Cell Citation Mol Cell. 2022 Jul 13:S1097-2765(22)00610-4. Abstract During gene transcription, RNA polymerase II (RNA Pol II) passes nucleosomes with the help of various elongation factors. Here, we show that RNA Pol II achieves efficient nucleosome passage

Authors Chen Y, Vos SM, Dienemann C, Ninov M, Urlaub H, Cramer P Journal Molecular Cell Citation Molecular Cell (2021). In press. Abstract The super elongation complex (SEC) contains the positive transcription elongation factor b (P-TEFb) and the subcomplex ELL2-EAF1, which stimulates RNA polymerase II (RNA Pol II) elongation. Here,

Authors Žumer K, Maier KC, Farnung L, Jaeger MG, Rus P, Winter G, Cramer P Journal Molecular Cell Citation Mol Cell. 2021 Jun 17:S1097-2765(21)00441-X. In press. Abstract Transcription by RNA polymerase II (RNA Pol II) relies on the elongation factors PAF1 complex (PAF), RTF1, and SPT6. Here, we use rapid

Authors Caizzi L, Monteiro-Martins S, Schwalb B, Lysakovskaia K, Schmitzova J, Sawicka A, Chen Y, Lidschreiber M, Cramer P Journal Molecular Cell Citation Mol Cell. 2021 May 6;81(9):1920-1934.e9. Abstract Transcription by RNA polymerase II (Pol II) is coupled to pre-mRNA splicing, but the underlying mechanisms remain poorly understood. Co-transcriptional splicing

Authors Rawat P, Boehning M, Hummel B, Aprile-Garcia F, Pandit AS, Eisenhardt N, Khavaran A, Niskanen E, Vos SM, Palvimo JJ, Pichler A, Cramer P, Sawarkar R Journal Molecular Cell Citation Mol Cell. 2021 Jan 28:S1097-2765(21)00016-2. Abstract In response to stress, human cells coordinately downregulate transcription and translation of housekeeping

Authors Lykke-Andersen S, Žumer K, Molska EŠ, Rouvière JO, Wu G, Demel C, Schwalb B, Schmid M, Cramer P, Jensen TH Journal Molecular Cell Citation Mol Cell. 2020 Dec 23:S1097-2765(20)30906-0. Abstract Termination of RNA polymerase II (RNAPII) transcription in metazoans relies largely on the cleavage and polyadenylation (CPA) and integrator