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13.10.2023

High-resolution analysis of bound Ca2+ in neurons and synapses

Authors Bonnin EA, Golmohammadi A, Rehm R, Tetzlaff C, Rizzoli SO Journal Life Science Alliance Citation Life Sci Alliance. 2023 Oct 13;7(1):e202302030. Abstract Calcium (Ca2+) is a well-known second messenger in all cells, and is especially relevant for neuronal activity. Neuronal Ca2+ is found in different forms, with a minority
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05.05.2022

Analyzing efficacy, stability, and safety of AAV-mediated optogenetic hearing restoration in mice

Authors Bali B, Gruber-Dujardin E, Kusch K, Rankovic V, Moser T Journal Life Science Alliance Citation Life Sci Alliance. 2022 May 5;5(8):e202101338 Abstract AAV-mediated optogenetic neural stimulation has become a clinical approach for restoring function in sensory disorders and feasibility for hearing restoration has been indicated in rodents. Nonetheless, long-term
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21.12.2021

Amyloid-like aggregates cause lysosomal defects in neurons via gain-of-function toxicity

Authors Riera-Tur I, Schäfer T, Hornburg D, Mishra A, da Silva Padilha M, Fernández-Mosquera L, Feigenbutz D, Auer P, Mann M, Baumeister W, Klein R, Meissner F, Raimundo N, Fernández-Busnadiego R, Dudanova I Journal Life Science Alliance Citation Life Sci Alliance. 2021 Dec 21;5(3):e202101185. Abstract The autophagy-lysosomal pathway is impaired
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