EMBO Molecular Medicine

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Is there an unmet medical need for improved hearing restoration?

Authors Wolf BJ, Kusch K, Hunniford V, Vona B, Kühler R, Keppeler D, Strenzke N, Moser T Journal EMBO Molecular Medicine Citation EMBO Mol Med. 2022 Jul 14:e15798. Abstract Hearing impairment, the most prevalent sensory deficit, affects more than 466 million people worldwide (WHO). We presently lack causative treatment for
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A microRNA signature that correlates with cognition and is a target against cognitive decline

Authors Islam MR, Kaurani L, Berulava T, Heilbronner U, Budde M, Centeno TP, Elerdashvili V, Zafieriou MP, Benito E, Sertel SM, Goldberg M, Senner F, Kalman JL, Burkhardt S, Oepen AS, Sakib MS, Kerimolgu C, Wirths O, Bickeböller H, Bartels C, Brosseron F, Buerger K, Cosma NC, Fliessbach K, Heneka
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Utility of red-light ultrafast optogenetic stimulation of the auditory pathway

Authors Bali B, Lopez de la Morena D, Mittring A, Mager T, Rankovic V, Huet AT, Moser T Journal EMBO Molecular Medicine Citation EMBO Mol Med. 2021 May 7:e13391. Abstract Optogenetic stimulation of spiral ganglion neurons (SGNs) in the ear provides a future alternative to electrical stimulation used in current
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Epigenetic gene expression links heart failure to memory impairment

Authors Islam MR, Lbik D, Sakib MS, Maximilian Hofmann R, Berulava T, Jiménez Mausbach M, Cha J, Goldberg M, Vakhtang E, Schiffmann C, Zieseniss A, Katschinski DM, Sananbenesi F, Toischer K, Fischer A Journal EMBO Molecular Medicine Citation EMBO Mol Med. 2021 Jan 20:e11900. Abstract In current clinical practice, care
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Quantitative analysis of hidden particles diffusing behind a scattering layer using speckle correlation

Authors Sarkar A, Wang I, Enderlein J, Derouard J, Delon A Journal Optics Express Citation Opt Express. 2020 Oct 26;28(22):32936-32954. Abstract Speckle-correlation imaging is a family of methods that makes use of the “memory effect” to image objects hidden behind visually opaque layers. Here, we show that a correlation analysis
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μLED-based optical cochlear implants for spectrally selective activation of the auditory nerve

Authors Dieter A, Klein E, Keppeler D, Jablonski L, Harczos T, Hoch G, Rankovic V, Paul O, Jeschke M, Ruther P, Moser T Journal EMBO Molecular Medicine Citation EMBO Mol Med. 2020 Jun 29;e12387. Abstract Electrical cochlear implants (eCIs) partially restore hearing and enable speech comprehension to more than half
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Towards the optical cochlear implant: optogenetic approaches for hearing restoration

Authors Dieter A, Keppeler D, Moser T Journal Cell Reports Citation EMBO Mol Med 2020 Apr 7;12(4):e11618. Abstract Cochlear implants (CIs) are considered the most successful neuroprosthesis as they enable speech comprehension in the majority of half a million CI users suffering from sensorineural hearing loss. By electrically stimulating the
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Fiber orientation in a whole mouse heart reconstructed by laboratory phase-contrast micro-CT

Authors Reichardt M, Topperwien M, Khan A, Alves F, Salditt T Journal Journal of Medical Imaging Citation J Med Imaging (Bellingham). 2020 Mar;7(2):023501. Abstract Purpose: We present a phase-contrast x-ray tomography study of wild type C57BL/6 mouse hearts as a nondestructive approach to the microanatomy on the scale of the
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Nanoscale x-ray holotomography of human brain tissue with phase retrieval based on multienergy recordings

Authors Robisch AL, Eckermann M, Topperwien M, van der Meer F, Stadelmann C, Salditt T Journal Journal of Medical Imaging Citation J Med Imaging (Bellingham) 2020 Jan;7(1). Abstract X-ray cone-beam holotomography of unstained tissue from the human central nervous system reveals details down to subcellular length scales. This visualization of
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A dual-AAV approach restores fast exocytosis and partially rescues auditory function in deaf otoferlin knock-out mice

Authors Al-Moyed H, Cepeda A P, Jung S, Moser T, Kugler S, Reisinger E Journal EMBO Molecular Medicine Citation EMBO Mol Med (2019) 11: e9396. Abstract Normal hearing and synaptic transmission at afferent auditory inner hair cell (IHC) synapses require otoferlin. Deafness DFNB9, caused by mutations in the OTOF gene
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