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23.12.2022

Optogenetics and electron tomography for structure-function analysis of cochlear ribbon synapses

Authors Chakrabarti R, Jaime Tobón LM, Slitin L, Redondo-Canales M, Hoch G, Slashcheva M, Fritsch E, Bodensiek K, Özçete ÖD, Gültas M, Michanski S, Opazo F, Neef J, Pangrsic T, Moser T, Wichmann C Journal elife Citation Elife. 2022 Dec 23;11:e79494. Abstract RRibbon synapses of cochlear inner hair cells (IHCs)
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18.11.2022

Munc13 supports fusogenicity of non-docked vesicles at synapses with disrupted active zones

Authors Tan C, de Nola G, Qiao C, Imig C, Born RT, Brose N, Kaeser PS Journal eLife Citation eLife 11:e79077. Abstract Active zones consist of protein scaffolds that are tightly attached to the presynaptic plasma membrane. They dock and prime synaptic vesicles, couple them to voltage-gated Ca2+ channels, and
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27.05.2022

Oct4 differentially regulates chromatin opening and enhancer transcription in pluripotent stem cells

Authors Xiong L, Tolen EA, Choi J, Velychko S, Caizzi L, Velychko T, Adachi K, MacCarthy CM, Lidschreiber M, Cramer P, Schoeler HR Journal eLife Citation eLife 11:e71533. Abstract The transcription factor Oct4 is essential for the maintenance and induction of stem cell pluripotency, but its functional roles are not
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21.03.2022

Stage-specific control of oligodendrocyte survival and morphogenesis by TDP-43

Authors Heo D, Ling JP, Molina-Castro GC, Langseth AJ, Waisman A, Nave KA, Möbius W, Wong PC, Bergles DE Journal Elife Citation eLife. 2022 Mar 21;11:e75230. Abstract Generation of oligodendrocytes in the adult brain enables both adaptive changes in neural circuits and regeneration of myelin sheaths destroyed by injury, disease,
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23.02.2022

Environmental enrichment enhances patterning and remodeling of synaptic nanoarchitecture as revealed by STED nanoscopy

Authors Wegner W, Steffens H, Gregor C, Wolf F, Willig KI Journal Elife Citation eLife 2022;11:e73603. Abstract Synaptic plasticity underlies long-lasting structural and functional changes to brain circuitry and its experience-dependent remodeling can be fundamentally enhanced by environmental enrichment. It is however unknown, whether and how the environmental enrichment alters
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31.12.2021

Defining the interactome of the human mitochondrial ribosome identifies SMIM4 and TMEM223 as respiratory chain assembly factors

Authors Dennerlein S, Poerschke S, Oeljeklaus S, Wang C, Richter-Dennerlein R, Sattmann J, Bauermeister D, Hanitsch E, Stoldt S, Langer T, Jakobs S, Warscheid B, Rehling P Journal Elife Citation Elife. 2021 Dec 31;10:e68213. Abstract Human mitochondria express a genome that encodes thirteen core subunits of the oxidative phosphorylation system
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21.12.2021

3D virtual histopathology of cardiac tissue from Covid-19 patients based on phase-contrast X-ray tomography

Authors Reichardt M, Moller Jensen P, Andersen Dahl V, Dahl AB, Ackermann M, Shah H, Länger F, Werlein C, Kuehnel MP, Jonigk D, Salditt T Journal Elife Citation eLife 2021;10:e71359. Abstract For the first time, we have used phase-contrast X-ray tomography to characterize the three-dimensional (3d) structure of cardiac tissue
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07.10.2021

The mammalian rod synaptic ribbon is essential for Cav channel facilitation and ultrafast synaptic vesicle fusion

Authors Grabner CP, Moser T Journal Elife Citation Elife. 2021 Oct 7;10:e63844. Abstract Rod photoreceptors (PRs) use ribbon synapses to transmit visual information. To signal ‘no light detected’ they release glutamate continually to activate post-synaptic receptors. When light is detected glutamate release pauses. How a rod’s individual ribbon enables this
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29.01.2021

Nanoscopic anatomy of dynamic multi-protein complexes at membranes resolved by graphene-induced energy transfer

Authors Füllbrunn N, Li Z, Jorde L, Richter CP, Kurre R, Langemeyer L, Yu C, Meyer C, Enderlein J, Ungermann C, Piehler J, You C Journal Elife Citation Elife. 2021 Jan 29;10:e62501. Abstract Insights into the conformational organization and dynamics of proteins complexes at membranes is essential for our mechanistic
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18.01.2021

Global and local tension measurements in biomimetic skeletal muscle tissues reveals early mechanical homeostasis

Authors Hofemeier AD, Limón T, Muenker TM, Wallmeyer B, Jurado A, Afshar ME, Ebrahimi M, Tsukanov R, Oleksiievets N, Enderlein J, Gilbert PM, Betz T Journal Elife Citation Elife. 2021 Jan 18;10:e60145. Abstract Tension and mechanical properties of muscle tissue are tightly related to proper skeletal muscle function, which makes
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