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28.01.2025

Computational functions of precisely balanced neuronal microcircuits in an olfactory memory network

Authors Meissner-Bernard C, Jenkins B, Rupprecht P, Bouldoires EA, Zenke F, Friedrich RW, Frank T Journal Cell Reports Citation Cell Reports 44, 115330, March 25, 2025. Abstract Models of balanced autoassociative memory networks predict that specific inhibition is critical to store information in connectivity. To explore these predictions, we characterized
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31.12.2024

A microscopy-based screen identifies cellular kinases modulating mitochondrial translation

Authors Yousefi R, Cruz-Zaragoza LD, Valpadashi A, Hansohn C, Dahal D, Richter-Dennerlein R, Rizzoli S, Urlaub H, Rehling P, Pacheu-Grau D Journal Cell Reports Citation Cell Rep, 44, 115143. Abstract Mitochondrial DNA encodes 13 subunits of the oxidative phosphorylation (OXPHOS) system, which are synthesized inside the organelle and essential for
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13.07.2024

Mutation-induced LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome

Authors Busley AV, Gutiérrez-Gutiérrez Ó, Hammer E, Koitka F, Mirzaiebadizi A, Steinegger M, Pape C, Böhmer L, Schroeder H, Kleinsorge M, Engler M, Cirstea IC, Gremer L, Willbold D, Altmüller J, Marbach F, Hasenfuss G, Zimmermann WH, Ahmadian MR, Wollnik B, Cyganek L Journal Cell Reports Citation Cell Rep. 2024
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16.02.2024

RNA helicase IGHMBP2 regulates THO complex to ensure cellular mRNA homeostasis

Authors Prusty AB, Hirmer A, Sierra-Delgado JA, Huber H, Guenther UP, Schlosser A, Dybkov O, Yildirim E, Urlaub H, Meyer KC, Jablonka S, Erhard F, Fischer U   Journal Cell Reports   Citation Cell Rep. 2024 Feb 16;43(2):113802.   Abstract RNA helicases constitute a large protein family implicated in cellular
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06.02.2023

Neuronal extracellular vesicles and associated microRNAs induce circuit connectivity downstream BDNF

Authors Antoniou A, Auderset L, Kaurani L, Sebastian E, Zeng Y, Allahham M, Cases-Cunillera S, Schoch S, Gruendemann J, Fischer A, Schneider A   Journal Cell Reports   Citation Cell Rep. 2023 Feb 6;42(2):112063.   Abstract Extracellular vesicles (EVs) have emerged as mediators of cellular communication, in part via the
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06.09.2022

Tackling the Dynamic Range Problem of Hearing: Diverse Hair Cell Synapses Enable Broad Neural Sound Intensity Coding

Authors Jaime Tobón LM, Moser T Journal Cell Reports Citation Cell Rep, 2022. under review. Abstract Synaptic heterogeneity can expand the encoding capacity of individual neurons or sensory cells. The afferent synapses between inner hair cells (IHCs) and spiral ganglion neurons (SGNs) in the cochlea exhibit marked heterogeneity in structure
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24.11.2021

The TFAM-to-mtDNA ratio defines inner-cellular nucleoid populations with distinct activity levels

Authors Brüser C, Keller-Findeisen J, Jakobs S Journal Cell Reports Citation Cell Reports 37, 110000, November 23, 2021. Abstract In human cells, generally a single mitochondrial DNA (mtDNA) is compacted into a nucleoprotein complex denoted the nucleoid. Each cell contains hundreds of nucleoids, which tend to cluster into small groups.
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01.06.2021

Multi-label in vivo STED microscopy by parallelized switching of reversibly switchable fluorescent proteins

Authors Willig KI, Wegner W, Müller A, Calvet-Fournier V, Steffens H Journal Cell Reports Citation Cell Reports. 2021 Jun 1; 35 (9) 109192. Abstract Despite the tremendous success of super-resolution microscopy, multi-color in vivo applications are still rare. Here we present live-cell multi-label STED microscopy in vivo and in vitro
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16.03.2021

Presynaptic activity and protein turnover are correlated at the single-synapse level

Authors Jähne S, Mikulasch F, Heuer HGH, Truckenbrodt S, Agüi-Gonzalez P, Grewe K, Vogts A, Rizzoli SO, Priesemann V Journal Cell Reports Citation Cell Reports 34, 108841, March 16, 2021. Abstract Synaptic transmission relies on the continual exocytosis and recycling of synaptic vesicles. Aged vesicle proteins are prevented from recycling
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12.01.2021

Vesicular Glutamate Transporters (SLCA17 A6, 7, 8) Control Synaptic Phosphate Levels

Authors Cheret C, Ganzella M, Preobraschenski J, Jahn R, Ahnert-Hilger G Journal Cell Reports Citation Cell Rep. 2021 Jan 12;34(2):108623. Abstract Vesicular glutamate transporters (VGLUTs) fill synaptic vesicles with glutamate. VGLUTs were originally identified as sodium-dependent transporters of inorganic phosphate (Pi), but the physiological relevance of this activity remains unclear.
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