Expected and Unexpected “Guests” at the Active Site of Human Orotidine 5′-Monophosphate Decarboxylase
Authors Kirck LL, Santagostino E, Brandhoff L, Simeth NA, Tittmann K Journal Biochemistry Citation Biochemistry. 2025 Oct 8. Abstract With an extraordinary rate enhancement of 1017 compared to the uncatalyzed reaction and no need for a cofactor, orotidine 5′-monophosphate decarboxylase (OMPDC) is considered one of the most efficient enzymes. Its
