Zelarayan-Behrend, Laura

Home >> Publications >> Author >> Zelarayan-Behrend, Laura
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22.01.2024

Preclinical evaluation of CRISPR-based therapies for Noonan syndrome caused by deep-intronic LZTR1 variants

Authors Knauer C, Haltern H, Schoger E, Kügler S, Roos L, Zelarayán LC, Hasenfuss G, Zimmermann WH, Wollnik B, Cyganek L Journal Molecular Therapy: Nucleic Acids Citation Mol Ther Nucleic Acids. 2024 Jan 23;35(1):102123. Abstract Gene variants in LZTR1 are implicated to cause Noonan syndrome associated with a severe and
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05.07.2023

Combining a tetracycline (Tet)-inducible gRNA system and CRISPRa for titratable and timely controlled enhancement of endogenous SHISA3 activation in human induced pluripotent stem cells (hiPSC)

Authors Priesmeier L, Schoger E, Cyganek L, Zelarayán LC Journal Stem Cell Research Citation Stem Cell Res. 2023 Jul 5;71:103163. Abstract Towards increasing the possibility for temporal control of gene expression using CRISPR activation (a) systems, we generated homozygous human induced pluripotent stem cell (hiPSC) lines carrying a doxycycline (dox)-inducible
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21.01.2023

Single-cell transcriptomics reveal extracellular vesicles secretion with a cardiomyocyte proteostasis signature during pathological remodeling

Authors Schoger E, Bleckwedel F, Germena G, Rocha C, Tucholla P, Sobitov I, Möbius W, Sitte M, Lenz C, Samak M, Hinkel R, Varga ZV, Giricz Z, Salinas G, Gross JC, Zelarayán LC Journal Communications Biology Citation Commun Biol. 2023 Jan 21;6(1):79. Abstract Aberrant Wnt activation has been reported in failing
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08.03.2022

A novel single-cell RNA-sequencing approach and its applicability connecting genotype to phenotype in ageing disease

Authors Shomroni O, Sitte M, Schmidt J, Parbin S, Ludewig F, Yigit G, Zelarayan LC, Streckfuss-Bömeke K, Wollnik B, Salinas G Journal Scientific Reports Citation Sci Rep. 2022 Mar 8;12(1):4091. Abstract Single cell multi-omics analysis has the potential to yield a comprehensive understanding of the cellular events that underlie the
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14.01.2022

Tailoring Cardiac Synthetic Transcriptional Modulation Towards Precision Medicine

Authors Schoger E, Lelek S, Panáková D, Zelarayán LC Journal Frontiers in Cardiovascular Medicine Citation Front Cardiovasc Med. 2022 Jan 14;8:783072. Abstract Molecular and genetic differences between individual cells within tissues underlie cellular heterogeneities defining organ physiology and function in homeostasis as well as in disease states. Transcriptional control of
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31.10.2021

Inactivation of Fgf3 and Fgf4 within the Fgf3/Fgf4/Fgf15 gene cluster reveals their redundant requirement for mouse inner ear induction and embryonic survival

Authors Zelarayan L, Vendrell V, Domínguez-Frutos E, López-Hernández I, Schimmang-Alonso K, Alonso MT, Alvarez Y, Maier H, Anderson MJ, Lewandoski M, Schimmang T. Journal Developmental Dynamics Citation Dev Dyn. 2021 Oct 31. Abstract Background Fibroblast growth factors (Fgfs) are required for survival and organ formation during embryogenesis. Fgfs often execute
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