Steinem, Claudia

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11.07.2023

HAV-Peptides Attached to Colloidal Probes Faithfully Detect E-Cadherins Displayed on Living Cells

Authors Toy S, Dietz J, Naumann P, Trothe J, Thomas F, Diederichsen U, Steinem C, Janshoff A Journal Chemistry – A European Journal Citation Chemistry. 2023 Jul 11;29(39):e202203904 Abstract Cell adhesion molecules are crucial for a variety of biological processes, including wound healing, barrier formation and tissue homeostasis. One of
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12.06.2023

Membrane-Bound Vimentin Filaments Reorganize and Elongate under Strain

Authors Nageswaran S, Haipeter J, Bodenschatz JFE, Meyer R, Köster S, Steinem C Journal Biomacromolecules Citation Biomacromolecules. 2023 Jun 12;24(6):2512-2521. Abstract Within a cell, intermediate filaments interact with other cytoskeletal components, altogether providing the cell’s mechanical stability. However, little attention has been drawn to intermediate filaments close to the plasma
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08.03.2023

Bioinspired Membrane Interfaces: Controlling Actomyosin Architecture and Contractility

Authors Liebe NL, Mey I, Vuong L, Shikho F, Geil B, Janshoff A, Steinem C Journal ACS Applied Materials & Interfaces Citation ACS Appl Mater Interfaces. 2023 Mar 8;15(9):11586-11598. Abstract The creation of biologically inspired artificial lipid bilayers on planar supports provides a unique platform to study membrane-confined processes in
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10.10.2022

From LUVs to GUVs – how to cover micrometer-sized pores with membranes

Authors Kramer K, Sari M, Schulze K, Flegel H, Stehr M, Mey I, Janshoff A, Steinem C Journal Journal of Physical Chemistry B Citation J. Phys. Chem. B 2022, 126, 41, 8233–8244. Abstract Pore-spanning membranes (PSMs) are a versatile tool to investigate membrane-confined processes in a bottom-up approach. Pore sizes
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04.01.2022

Forces, Kinetics, and Fusion Efficiency Altered by the Full-Length Synaptotagmin‑1 -PI(4,5)P2 Interaction in Constrained Geometries

Authors Dietz J, Oelkers M, Hubrich R, Pérez-Lara A, Jahn R, Steinem C, Janshoff A Journal Nano Letters Citation Nano Lett. 2022, Jan 4 Abstract A mechanism for full-length synaptotagmin-1 (syt-1) to interact with anionic bilayers and to promote fusion in the presence of SNAREs is proposed. Colloidal probe force
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27.05.2021

Pore-Spanning Plasma Membranes Derived from Giant Plasma Membrane Vesicles

Authors Teiwes NK, Mey I, Baumann PC, Strieker L, Unkelbach U, Steinem C Journal ACS Applied Materials & Interfaces Citation ACS Appl Mater Interfaces. 2021 Jun 9;13(22):25805-25812. Abstract Giant plasma membrane vesicles (GPMVs) are a highly promising model system for the eukaryotic plasma membrane. The unresolved challenge, however, is a
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14.05.2021

Insights into the molecular mechanism of amyloid filament formation: Segmental folding of α-synuclein on lipid membranes

Authors Antonschmidt L, Dervişoğlu R, Sant V, Movellan KT, Mey I, Riedel D, Steinem C, Becker S, Andreas LB, Griesinger C Journal Science Advances Citation Sci Adv. 2021 May 14;7(20):eabg2174. Abstract Recent advances in the structural biology of disease-relevant α-synuclein fibrils have revealed a variety of structures, yet little is
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03.03.2021

An antibiotic-resistance conferring mutation in a neisserial porin: Structure, ion flux, and ampicillin binding

Authors Bartsch A, Ives CM, Kattner C, Pein F, Diehn M, Tanabe M, Munk A, Zachariae U, Steinem C, Llabrés S Journal Biochimica et Biophysica Acta – Biomembranes Citation Biochim Biophys Acta Biomembr. 2021 Mar 3:183601. Abstract Gram-negative bacteria cause the majority of highly drug-resistant bacterial infections. To cross the
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14.10.2020

Heterogeneous Idealization of Ion Channel Recordings — Open Channel Noise

Authors Pein F, Bartsch A, Steinem C, Munk A Journal IEEE Transactions on Nanobioscience Citation IEEE Trans Nanobioscience. 2020 Oct 14;PP. Abstract We propose a new model-free segmentation method for idealizing ion channel recordings. This method is designed to deal with heterogeneity of measurement errors. This in particular applies to
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04.02.2019

High-resolution experimental and computational electrophysiology reveals weak beta-lactam binding events in the porin PorB

Authors Bartsch A, Llabres S, Pein F, Kattner C, Schon M, Diehn M, Tanabe M, Munk A, Zachariae U, Steinem C Journal Scientific Reports Citation Sci Rep. 2019 Feb 4;9(1):1264. Abstract The permeation of most antibiotics through the outer membrane of Gram-negative bacteria occurs through porin channels. To design drugs
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