Steinem, Claudia

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23.05.2024

CaV1.3 channel clusters characterized by live-cell and isolated plasma membrane nanoscopy

Authors Schwenzer N, Teiwes NK, Kohl T, Pohl C, Giller MJ, Lehnart SE, Steinem C Journal Communications Biology Citation Commun Biol. 2024 May 23;7(1):620. Abstract A key player of excitable cells in the heart and brain is the L-type calcium channel CaV1.3. In the heart, it is required for voltage-dependent
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27.03.2024

Chemical synthesis of site-selective advanced glycation end products in α-synuclein and its fragments

Authors Bosbach C, Gatzemeier LM, Bloch von Blottnitz KI, König A, Diederichsen U, Steinem C, Outeiro TF Journal Organic & Biomolecular Chemistry Citation Org Biomol Chem. 2024 Mar 27;22(13):2670-2676. Abstract Advanced glycation end products (AGEs) arise from the Maillard reaction between dicarbonyls and proteins, nucleic acids, or specific lipids. Notably,
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19.03.2024

Robust inference of cooperative behaviour of multiple ion channels in voltage-clamp recordings

Authors Requardt R, Fink M, Kubica P, Steinem C, Munk A, Li H   Journal Arxiv   Citation arXiv:2403.13197.   Abstract Recent experimental studies have shed light on the intriguing possibility that ion channels exhibit cooperative behaviour. However, a comprehensive understanding of such cooperativity remains elusive, primarily due to limitations
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17.10.2023

Fluorophore position of headgroup-labeled Gb3 glycosphingolipids in lipid bilayers

Authors Socrier L, Sharma A, Chen T, Flato K, Kettelhoit K, Enderlein J, Werz DB, Steinem C Journal Biophysical Journal Citation Biophys J. 2023 Oct 17;122(20):4104-4112. Abstract Fluorescent lipid probes are an invaluable tool for investigating lipid membranes. In particular, localizing certain receptor lipids such as glycosphingolipids within phase-separated membranes
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11.07.2023

HAV-Peptides Attached to Colloidal Probes Faithfully Detect E-Cadherins Displayed on Living Cells

Authors Toy S, Dietz J, Naumann P, Trothe J, Thomas F, Diederichsen U, Steinem C, Janshoff A Journal Chemistry Citation Chemistry. 2023 Jul 11;29(39):e202203904. Abstract Cell adhesion molecules are crucial for a variety of biological processes, including wound healing, barrier formation and tissue homeostasis. One of them is E-cadherin which
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11.07.2023

HAV-Peptides Attached to Colloidal Probes Faithfully Detect E-Cadherins Displayed on Living Cells

Authors Toy S, Dietz J, Naumann P, Trothe J, Thomas F, Diederichsen U, Steinem C, Janshoff A Journal Chemistry – A European Journal Citation Chemistry. 2023 Jul 11;29(39):e202203904 Abstract Cell adhesion molecules are crucial for a variety of biological processes, including wound healing, barrier formation and tissue homeostasis. One of
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12.06.2023

Membrane-Bound Vimentin Filaments Reorganize and Elongate under Strain

Authors Nageswaran S, Haipeter J, Bodenschatz JFE, Meyer R, Köster S, Steinem C Journal Biomacromolecules Citation Biomacromolecules. 2023 Jun 12;24(6):2512-2521. Abstract Within a cell, intermediate filaments interact with other cytoskeletal components, altogether providing the cell’s mechanical stability. However, little attention has been drawn to intermediate filaments close to the plasma
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08.03.2023

Bioinspired Membrane Interfaces: Controlling Actomyosin Architecture and Contractility

Authors Liebe NL, Mey I, Vuong L, Shikho F, Geil B, Janshoff A, Steinem C Journal ACS Applied Materials & Interfaces Citation ACS Appl Mater Interfaces. 2023 Mar 8;15(9):11586-11598. Abstract The creation of biologically inspired artificial lipid bilayers on planar supports provides a unique platform to study membrane-confined processes in
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10.10.2022

From LUVs to GUVs – how to cover micrometer-sized pores with membranes

Authors Kramer K, Sari M, Schulze K, Flegel H, Stehr M, Mey I, Janshoff A, Steinem C Journal Journal of Physical Chemistry B Citation J. Phys. Chem. B 2022, 126, 41, 8233–8244. Abstract Pore-spanning membranes (PSMs) are a versatile tool to investigate membrane-confined processes in a bottom-up approach. Pore sizes
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04.01.2022

Forces, Kinetics, and Fusion Efficiency Altered by the Full-Length Synaptotagmin‑1 -PI(4,5)P2 Interaction in Constrained Geometries

Authors Dietz J, Oelkers M, Hubrich R, Pérez-Lara A, Jahn R, Steinem C, Janshoff A Journal Nano Letters Citation Nano Lett. 2022, Jan 4 Abstract A mechanism for full-length synaptotagmin-1 (syt-1) to interact with anionic bilayers and to promote fusion in the presence of SNAREs is proposed. Colloidal probe force
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