Sakata, Eri

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28.02.2024

Inhibition of 26S proteasome activity by α-synuclein is mediated by the proteasomal chaperone Rpn14/PAAF1

Authors Galka D, Ali TT, Bast A, Niederleithinger M, Gerhardt E, Motosugi R, Sakata E, Knop M, Outeiro TF, Popova B, Braus GH   Journal Aging Cell   Citation Aging Cell. 2024 Feb 28:e14128.   Abstract Parkinson’s disease (PD) is characterized by aggregation of α-synuclein (α-syn) into protein inclusions in
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07.02.2024

Characterizing ATP processing by the AAA+ protein p97 at the atomic level

Authors Shein M, Hitzenberger M, Cheng T, Rout S, Leitl K, Sato Y, Zacharias M, Sakata E, Schuetz A Journal Nature Chemistry Citation Nat. Chem. (2024). Abstract The human enzyme p97 regulates various cellular pathways by unfolding hundreds of protein substrates in an ATP-dependent manner, making it an essential component
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12.12.2022

Mono- and Intralink Filter (Mi-Filter) To Reduce False Identifications in Cross-Linking Mass Spectrometry Data

Authors Chen X, Sailer C, Kammer KM, Fürsch J, Eisele MR, Sakata E, Pellarin R, Stengel F Journal Analytical Chemistry Citation Anal. Chem. 2022, 94, 51, 17751–17756. Abstract Cross-linking mass spectrometry (XL-MS) has become an indispensable tool for the emerging field of systems structural biology over the recent years. However,
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11.02.2022

Allosteric control of Ubp6 and the proteasome via a bidirectional switch

Authors Hung KYS, Klumpe S, Eisele MR, Elsasser S, Tian G, Sun S, Moroco JA, Cheng TC, Joshi T, Seibel T, Van Dalen D, Feng XH, Lu Y, Ovaa H, Engen JR, Lee BH, Rudack T, Sakata E, Finley D Journal Nature Communications Citation Nat Commun. 2022 Feb 11;13(1):838. Abstract
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01.03.2021

Molecular and cellular dynamics of the 26S proteasome

Authors Sakata E, Eisele MR, Baumeister W Journal Biochimica et Biophysica Acta – Proteins and Proteomics Citation Biochim Biophys Acta Proteins Proteom. 2021 Mar;1869(3):140583. Epub 2020 Dec 13. Abstract In eukaryotic cells, the ubiquitin-proteasome system serves to remove proteins that are either dysfunctional or no longer needed. The 26S proteasome
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