Bohnsack, Markus

Authors Höbartner C, Bohnsack KE, Bohnsack MT Journal Annual Review of Biochemistry Citation Annu Rev Biochem. 2024 Apr 10. Abstract Methylation of RNA nucleotides represents an important layer of gene expression regulation, and perturbation of the RNA methylome is associated with pathophysiology. In cells, RNA methylations are installed by RNA

Authors Kanwal N, Krogh N, Memet I, Lemus-Diaz N, Thomé CC, Welp LM, Mizi A, Hackert P, Papantonis A, Urlaub H, Nielsen H, Bohnsack KE, Bohnsack MT Journal Nucleic Acids Research Citation Nucleic Acids Res. 2023 Dec 19:gkad1202. Abstract Regulation of RNA helicase activity, often accomplished by protein cofactors, is

Authors Wang C, Ulryck N, Herzel L, Pythoud N, Kleiber N, Guérineau V, Jactel V, Moritz C, Bohnsack MT, Carapito C, Touboul D, Bohnsack KE, Graille M Journal Nucleic Acids Research Citation Nucleic Acids Res. 2023 Jun 7:gkad487. Abstract Modified nucleotides in non-coding RNAs, such as tRNAs and snRNAs, represent

Authors Castro-Hernández R, Berulava T, Metelova M, Epple R, Peña Centeno T, Sakib MS, Burkhart S, Ninov M, Bohnsack KE, Bohnsack MT, Delalle I, Fischer A Journal Proceedings of the National Academy of Sciences Citation Proc Natl Acad Sci U S A. 2023 Feb 28;120(9):e2204933120. Abstract N6-methyladenosine (m6A) regulates mRNA

Authors Bohnsack KE, Kleiber N, Lemus-Diaz N, Bohnsack MT Journal Trends in Biochemical Sciences Citation Trends Biochem Sci. 2022 Mar 29:S0968-0004(22)00063-9. Abstract Modified nucleotides within cellular RNAs significantly influence their biogenesis, stability, and function. As reviewed here, 3-methylcytidine (m3C) has recently come to the fore through the identification of the

Authors Kleiber N, Lemus-Diaz N, Siller C, Heinrichs M, Mai MMQ, Hackert P, Richter-Dennerlein R, Höbartner C, Bohnsack KE, Bohnsack MT Journal Nature Communications Citation Nat Commun 13, 209 (2022). Abstract Modified nucleotides in tRNAs are important determinants of folding, structure and function. Here we identify METTL8 as a mitochondrial

Authors Cruz-Zaragoza LD, Dennerlein S, Linden A, Yousefi R, Lavdovskaia E, Aich A, Falk RR, Gomkale R, Schöndorf T, Bohnsack MT, Richter-Dennerlein R, Urlaub H, Rehling P Journal Cell Citation Cell 2021 Oct 20. Abstract The human mitochondrial genome encodes thirteen core subunits of the oxidative phosphorylation system, and defects

Authors Lemus-Diaz N, Ferreira RR, Bohnsack KE, Gruber J, Bohnsack MT Journal Nucleic Acids Research Citation Nucleic Acids Res. 2020;gkaa549. published online ahead of print, 2020 Jul 1. Abstract MicroRNAs (miRNAs) are important regulators of eukaryotic gene expression and their dysfunction is often associated with cancer. Alongside the canonical miRNA

Authors Berulava T, Buchholz E, Elerdashvili V, Pena T, Islam MR, Lbik D, Mohamed BA, Renner A, von Lewinski D, Sacherer M, Bohnsack KE, Bohnsack MT, Jain G, Capece V, Cleve N, Burkhardt S, Hasenfuss G, Fischer A, Toischer K Journal European Journal of Heart Failure Citation Eur J Heart