Betz, TImo

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28.02.2025

Optimizing Electrical Field Stimulation Parameters Reveals the Maximum Contractile Function of Human Skeletal Muscle Microtissues

Authors Tiper Y, Xie Z, Hofemeier AD, Lad H, Luber M, Krawetz R, Betz T, Zimmermann WH, Morton AB, Segal SS, Gilbert PM. Journal American Journal of Physiology. Cell Physiology Citation Am J Physiol Cell Physiol. 2025 Feb 28. Abstract Skeletal muscle microtissues are engineered to develop therapies for restoring
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20.02.2025

Direct mechanical communication of cellular to nuclear shape in oocytes

Authors Vos BE, Vadapalli Y, Muenker TM, Jentoft IMA, Todisco E, Eskandari MA, Schuh M, Lenart P, Betz T Journal BioRxiv Citation bioRxiv 2025.02.17.638579. Abstract The mechanical properties of the cytoplasm and nucleoplasm are crucial for the correct and robust functioning of a cell and play a key role in
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24.01.2025

Active Intracellular Mechanics: A Key to Cellular Function and Organization

Authors Eskandari MA, Fischer J, Veyret N, Marx D, Betz T Journal Arxiv Citation arXiv:2501.14538. Abstract While mechanobiology has demonstrated that precise control over mechanical properties at the whole-cell level is crucial for many biological functions, comparatively little attention has been paid to the intracellular mechanical properties. Experimental tools have
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22.01.2025

3D dynamic multiscale force and shape analysis of in-vivo elastic stress sensors

Authors Jimenez AJ, Isensee J, Hofemeier A, Krueger LJ, Wittkowski R, Golestanian R, Bittihn P, Betz T Journal BioRxiv Citation bioRxiv 2025.01.22.633835. Abstract The measurement of stresses and forces at the tissue level has proven to be an indispensable tool for the understanding of complex biological phenomena such as cancer
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03.10.2024

Membrane tension regulation is required for wound repair

Authors Raj N, Weiss M, Vos BE, Weischer S, Brinkmann F, Betz T, Trappmann B, Gerke V Journal Advanced Science Citation Adv Sci (Weinh). 2024 Oct 3:e2402317. Abstract Disruptions of the eukaryotic plasma membrane due to chemical and mechanical challenges are frequent and detrimental and thus need to be repaired
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31.07.2024

Accessing activity and viscoelastic properties of artificial and living systems from passive measurement

Authors Muenker TM, Knotz G, Krüger M, Betz T Journal Nature Materials Citation Nat Mater. 2024 Jul 31. Abstract Living systems are complex dynamic entities that operate far from thermodynamic equilibrium. Their active, non-equilibrium behaviour requires energy to drive cellular organization and dynamics. Unfortunately, most statistical mechanics approaches are not
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01.06.2024

Characterizing intracellular mechanics via optical tweezers-based microrheology

Authors Vos BE, Muenker TM, Betz T Journal Current Opinion in Cell Biology Citation Curr Opin Cell Biol. 2024 Jun 1;88:102374. Abstract Intracellular organization is a highly regulated homeostatic state maintained to ensure eukaryotic cells’ correct and efficient functioning. Thanks to decades of research, vast knowledge of the proteins involved
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29.05.2024

Intracellular mechanical fingerprint reveals cell type specific mechanical tuning

Authors Muenker TM, Vos BE, Betz T Journal eLife Citation eLife13:RP97416. Abstract Living cells are complex entities that perform many different complex tasks with astonishing robustness. While the direct dependence of biological processes on controlled protein expression is well established, we only begin to understand how intracellular mechanical characteristics guide
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29.02.2024

Variance sum rule for entropy production

Authors Di Terlizzi I, Gironella M, Herraez-Aguilar D, Betz T, Monroy F, Baiesi M, Ritort F   Journal Science   Citation Science. 2024 Mar;383(6686):971-976.   Abstract Entropy production is the hallmark of nonequilibrium physics, quantifying irreversibility, dissipation, and the efficiency of energy transduction processes. Despite many efforts, its measurement at
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11.04.2023

Roadmap for Optical Tweezers

Authors Volpe G, Maragò OM, Rubinzstein-Dunlop H, Pesce G, Stilgoe AB, Volpe G, Tkachenko G, Truong VG, Chormaic SN, Kalantarifard F, Elahi P, Käll M, Callegari A, Marqués MI, Neves AAR, Moreira WL, Fontes A, Cesar CL, Saija R, Saidi A, Beck P, Eismann JS, Banzer P, Fernandes TFD, Pedaci
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