Betz, TImo

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01.06.2024

Characterizing intracellular mechanics via optical tweezers-based microrheology

Authors Vos BE, Muenker TM, Betz T Journal Current Opinion in Cell Biology Citation Curr Opin Cell Biol. 2024 Jun 1;88:102374. Abstract Intracellular organization is a highly regulated homeostatic state maintained to ensure eukaryotic cells’ correct and efficient functioning. Thanks to decades of research, vast knowledge of the proteins involved
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15.03.2024

Intracellular mechanical fingerprint reveals cell type specific mechanical tuning

Authors Muenker TM, Vos BE, Betz T Journal BioRxiv Citation bioRxiv 2023.08.10.552769. Abstract Living cells are complex entities that perform many different complex tasks with astonishing robustness. While the direct dependence of biological processes on controlled protein expression is well established, we only begin to understand how intracellular mechanical characteristics
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29.02.2024

Variance sum rule for entropy production

Authors Di Terlizzi I, Gironella M, Herraez-Aguilar D, Betz T, Monroy F, Baiesi M, Ritort F   Journal Science   Citation Science. 2024 Mar;383(6686):971-976.   Abstract Entropy production is the hallmark of nonequilibrium physics, quantifying irreversibility, dissipation, and the efficiency of energy transduction processes. Despite many efforts, its measurement at
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11.04.2023

Roadmap for Optical Tweezers

Authors Volpe G, Maragò OM, Rubinzstein-Dunlop H, Pesce G, Stilgoe AB, Volpe G, Tkachenko G, Truong VG, Chormaic SN, Kalantarifard F, Elahi P, Käll M, Callegari A, Marqués MI, Neves AAR, Moreira WL, Fontes A, Cesar CL, Saija R, Saidi A, Beck P, Eismann JS, Banzer P, Fernandes TFD, Pedaci
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23.12.2022

Dystrophin is a mechanical tension modulator

Authors Hofemeier AD, Muenker TM, Herkenrath F, Ristau M, Brandt M, Shahriyari M, Tiburcy M, Zimmermann WH, Lenz C, Mamchaoui K, Bigot A, Gilbert PM, Betz T Journal BioRxiv Citation bioRxiv 2022.12.23.521750. Abstract Duchenne muscular dystrophy (DMD) represents the most common inherited muscular disease, where increasing muscle weakness leads to
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21.10.2021

Intracellular softening and increased viscoelastic fluidity during division

Authors Hurst S, Vos BE, Brandt M, Betz T Journal Nature Physics Citation Nat. Phys. (2021). Abstract The life and death of an organism rely on correct cell division, which occurs through the process of mitosis. Although the biochemical signalling and morphogenetic processes during mitosis are well understood, the importance
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18.01.2021

Global and local tension measurements in biomimetic skeletal muscle tissues reveals early mechanical homeostasis

Authors Hofemeier AD, Limón T, Muenker TM, Wallmeyer B, Jurado A, Afshar ME, Ebrahimi M, Tsukanov R, Oleksiievets N, Enderlein J, Gilbert PM, Betz T Journal Elife Citation Elife. 2021 Jan 18;10:e60145. Abstract Tension and mechanical properties of muscle tissue are tightly related to proper skeletal muscle function, which makes
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