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25.03.2024

Regulation of Zbp1 by miR-99b-5p in microglia controls the development of schizophrenia-like symptoms in mice

Authors Kaurani L, Islam MR, Heilbronner U, Krüger DM, Zhou J, Methi A, Strauss J, Pradhan R, Schröder S, Burkhardt S, Schuetz AL, Pena T, Erlebach L, Bühler A, Budde M, Senner F, Kohshour MO, Schulte EC, Schmauß M, Reininghaus EZ, Juckel G, Kronenberg-Versteeg D, Delalle I, Odoardi F, Flügel
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25.03.2024

Gene therapy for deafness: are we there now?

Authors Moser T, Chen H, Kusch K, Behr R, Vona B   Journal EMBO Molecular Medicine   Citation EMBO Mol Med. 2024 Mar 25.   Abstract No abstract available.   DOI 10.1038/s44321-024-00058-6   Pubmed Link
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21.03.2024

Unbiased complexome profiling and global proteomics analysis reveals mitochondrial impairment and potential changes at the intercalated disk in presymptomatic R14Delta/+ mice hearts

Authors Foo B, Amedei H, Kaur S, Jaawan S, Boshnakovska A, Gall T, de Boer RA, Sillje HHW, Urlaub H, Rehling P, Lenz C, Lehnart SE   Journal BioRxiv   Citation bioRxiv 2024.03.21.586093.   Abstract Background: Phospholamban (PLN) is a sarco-endoplasmic reticulum (SER) membrane protein that regulates cardiac contraction/relaxation by
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20.03.2024

METTL3-dependent m6A modification of PSEN1 mRNA regulates craniofacial development through the Wnt/β-catenin signaling pathway

Authors Ma L, Zhou X, Yao S, Zhang X, Mao J, Vona B, Fan L, Lou S, Li D, Wang L, Pan Y   Journal Cell Death & Disease   Citation Cell Death Dis 15, 229 (2024).   Abstract Craniofacial malformations, often associated with syndromes, are prevalent birth defects. Emerging
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19.03.2024

The SecM arrest peptide traps a pre-peptide bond formation state of the ribosome

Authors Gersteuer F, Morici M, Gabrielli S, Fujiwara K, Safdari HA, Paternoga H, Bock LV, Chiba S, Wilson DN   Journal Nature Communications   Citation Nat Commun. 2024 Mar 19;15(1):2431.   Abstract Nascent polypeptide chains can induce translational stalling to regulate gene expression. This is exemplified by the E. coli
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19.03.2024

RAPP-containing arrest peptides induce translational stalling by short circuiting the ribosomal peptidyltransferase activity

Authors Morici M, Gabrielli S, Fujiwara K, Paternoga H, Beckert B, Bock LV, Chiba S, Wilson DN   Journal Nature Communications   Citation Nat Commun. 2024 Mar 19;15(1):2432.   Abstract Arrest peptides containing RAPP (ArgAlaProPro) motifs have been discovered in both Gram-positive and Gram-negative bacteria, where they are thought to
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19.03.2024

Adsorption of alpha-synuclein and inhibition of fibril formation by nanocellulose and gold-coated-nanocellulose

Authors Lamtar Mohammadi EL, Keikha R, Outeiro TF, Jebali A   Journal Cellulose   Citation Cellulose (2024)   Abstract Interfering with the aggregation of the protein alpha-synuclein (aSyn) has been a topic of research for > 25 years, as this protein is found in pathognomonic protein aggregates in the brain of
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19.03.2024

Robust inference of cooperative behaviour of multiple ion channels in voltage-clamp recordings

Authors Requardt R, Fink M, Kubica P, Steinem C, Munk A, Li H   Journal Arxiv   Citation arXiv:2403.13197.   Abstract Recent experimental studies have shed light on the intriguing possibility that ion channels exhibit cooperative behaviour. However, a comprehensive understanding of such cooperativity remains elusive, primarily due to limitations
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17.03.2024

Multiscale Quantile Regression with Local Error Control

Authors Liu Z, Li H   Journal Arxiv   Citation arXiv:2403.11356.   Abstract For robust and efficient detection of change points, we introduce a novel methodology MUSCLE (multiscale quantile segmentation controlling local error) that partitions serial data into multiple segments, each sharing a common quantile. It leverages multiple tests for
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29.02.2024

Structure of the multi-subunit chloroplast RNA polymerase

Authors do Prado PFV, Ahrens FM, Liebers M, Ditz N, Braun HP, Pfannschmidt T, Hillen HS   Journal Molecular Cell   Citation Mol Cell (2024) 84, 1–16.   Abstract Chloroplasts contain a dedicated genome that encodes subunits of the photosynthesis machinery. Transcription of photosynthesis genes is predominantly carried out by
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