2024

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Representation of the highly sensitive detector that is part of the newly developed fluorescence microscope. It consists of 23 individual detectors, enabling the resolution to be doubled. Photo: Alexey Chizhik, Göttingen University

02.08.2024

Glimpse into the nanoworld: microscope reveals tiniest cell processes

Research team including Göttingen University develops high-resolution fluorescence microscope   What does the inside of a cell really look like? In the past, standard microscopes were limited in how well they could answer this question. Now, researchers from the Universities of Göttingen and Oxford, in collaboration with the University Medical
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02.08.2024

Doubling the resolution of fluorescence-lifetime single-molecule localization microscopy with image scanning microscopy

Authors Radmacher N, Nevskyi O, Gallea JI, Thiele JC, Gregor I, Rizzoli SO, Enderlein J Journal Nature Photonics Citation Nat. Photon. (2024). Abstract In this study, we integrate a single-photon detector array into a confocal laser scanning microscope, enabling the combination of fluorescence-lifetime single-molecule localization microscopy with image scanning microscopy.
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01.08.2024

mini-Complexome Profiling (mCP), an FDR-controlled workflow for global targeted detection of protein complexes

Authors Amedei H, Paul NB, Foo B, Neuenroth L, Lehnart SE, Urlaub H, Lenz C Journal BioRxiv Citation Front. Anal. Sci. 4:1425190. Abstract Introduction: Co-fractionation mass spectrometry couples native-like separations of protein-protein complexes with mass spectrometric proteome analysis for global characterization of protein networks. The technique allows for both de
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A view into the cell using an optical laser trap: it localizes microscopic particles in order to draw conclusions about their random trembling movement. A new approach developed by the Göttingen researchers makes it possible to deduce from these movements how hard, soft or liquid the inside of the cell is. Photo: Till Moritz Münker

31.07.2024

“Laser view” into the avocado: new method reveals cell interior

Research team at the University of Göttingen develops method for recognizing cell properties   Checking whether an avocado is hard or soft by looking at it? This would require recognizing how the plant cells behave behind the skin. The same applies to all other cells on our planet: Despite more
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31.07.2024

Accessing activity and viscoelastic properties of artificial and living systems from passive measurement

Authors Muenker TM, Knotz G, Krüger M, Betz T Journal Nature Materials Citation Nat Mater. 2024 Jul 31. Abstract Living systems are complex dynamic entities that operate far from thermodynamic equilibrium. Their active, non-equilibrium behaviour requires energy to drive cellular organization and dynamics. Unfortunately, most statistical mechanics approaches are not
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28.07.2024

Helical superstructures between amyloid and collagen VI in heart-derived fibrils from a patient with Light Chain Amyloidosis

Authors Schulte T, Chaves-Sanjuan A, Speranzini V, Sicking K, Milazzo M, Mazzini G, Rognoni P, Caminito S, Milani P, Marabelli C, Corbelli A, Diomede L, Fiordaliso F, Anastasia L, Pappone C, Merlini G, Bolognesi M, Nuvolone M, Fernández-Busnadiego R, Palladini G, Ricagno S Journal Nature Communications Citation Nat Commun. 2024
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24.07.2024

Microlens arrays for multichannel laser-to-waveguide coupling

Authors Kunze K, Gossler C, Peters V, Keppeler D, Moser T, Schwarz UT Journal Applied Optics Citation Appl. Opt. 63, 5876-5885 (2024). Abstract An optical multichannel coupling system for coupling laser arrays to waveguide arrays is developed. Based on a microlens array, the system enables coupling of nine individual optical
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21.07.2024

Distributional limits of graph cuts on discretized grids

Authors Suchan L, Li H, Munk A Journal Arxiv Citation arXiv:2407.15297. Abstract Graph cuts are among the most prominent tools for clustering and classification analysis. While intensively studied from geometric and algorithmic perspectives, graph cut-based statistical inference still remains elusive to a certain extent. Distributional limits are fundamental in understanding
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19.07.2024

Peripheral whole blood microRNA expression in relation to vascular function: a population-based study

Authors Talevi V, Melas K, Pehlivan G, Imtiaz MA, Krüger DM, Centeno TP, Aziz NA, Fischer A, Breteler MMB Journal Journal of Translational Medicine Citation J Transl Med. 2024 Jul 19;22(1):670. Abstract Background: As key regulators of gene expression, microRNAs affect many cardiovascular mechanisms and have been associated with several
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16.07.2024

Dysferlin Enables Tubular Membrane Proliferation in Cardiac Hypertrophy

Authors Paulke NJ, Fleischhacker C, Wegener JB, Riedemann GC, Cretu C, Mushtaq M, Zaremba N, Möbius W, Zühlke Y, Wedemeyer J, Liebmann L, Gorshkova AA, Kownatzki-Danger D, Wagner E, Kohl T, Wichmann C, Jahn O, Urlaub H, Toischer K, Hasenfuß G, Moser T, Preobraschenski J, Lenz C, Rog-Zielinska EA, Lehnart
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