2022

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01.06.2022

Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model: A randomised, double-blind, placebo-controlled phase 1a trial

Authors Levin J, Sing N, Melbourne S, Morgan A, Mariner C, Spillantini MG, Wegrzynowicz M, Dalley JW, Langer S, Ryazanov S, Leonov A, Griesinger C, Schmidt F, Weckbecker D, Prager K, Matthias T, Giese A Journal eBioMedicine Citation EBioMedicine. 2022 Jun;80:104021 Abstract Background: Synucleinopathies such as Parkinson ́ s disease
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01.06.2022

Statistical Methods for Minimax Estimation in Linear Models with Unknown Design Over Finite Alphabets

Authors Behr M, Munk A Journal SIAM Journal on Mathematics of Data Science Citation SIAM Journal on Mathematics of Data Science 4(2):490-513. Abstract We provide a minimax optimal estimation procedure for F and W in matrix valued linear models Y = F W + Z where the parameter matrix W
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31.05.2022

A fluorescent nanosensor paint detects dopamine release at axonal varicosities with high spatiotemporal resolution

Authors Elizarova S, Chouaib A, Shaib A, Hill B, Mann F, Brose N, Kruss S, Daniel JA Journal PNAS Citation Proc Natl Acad Sci U S A. 2022 May 31;119(22):e2202842119. Abstract The neurotransmitter dopamine controls normal behavior and dopaminergic dysfunction is prevalent in multiple brain diseases. To reach a detailed
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Prof. Dr. Tiago Outeiro und Dr. Annekatrin König, Abteilung für Experimentelle Neurodegeneration der UMG. Foto: umg/spförtner

31.05.2022

Tiago Outeiro and Annekatrin König receive Parkinson’s Foundation Innovation Award

The “Parkinson Foundation” honors scientists of the University Medical Center Göttingen for their project proposal “Glycation of alpha-synuclein as biomarker” with the Innovation Award in the category “Basic Research”. The Innovation Prize is endowed with 100 000 euros. Dr. Annekatrin König, research associate, and Prof. Dr. Tiago Fleming Outeiro, MBExC
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27.05.2022

Oct4 differentially regulates chromatin opening and enhancer transcription in pluripotent stem cells

Authors Xiong L, Tolen EA, Choi J, Velychko S, Caizzi L, Velychko T, Adachi K, MacCarthy CM, Lidschreiber M, Cramer P, Schoeler HR Journal eLife Citation eLife 11:e71533. Abstract The transcription factor Oct4 is essential for the maintenance and induction of stem cell pluripotency, but its functional roles are not
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The cell body in the centre of a dopamine nerve cell and the branch-like receiving nerve cell processes are shown in magenta, complex branched axons in light blue and the axon areas responsible for dopamine release in red. © Elizarova, Kruss & Daniel / Max Planck Institute for Multidisciplinary Sciences

27.05.2022

Dopamine nanosensors measure signaling between nerve cells

Göttingen researchers succeeded in measuring the release of the neurotransmitter dopamine from nerve cells with unprecedented accuracy. This enables scientists to study the mechanisms that control dopamine signaling in more detail and to better elucidate the development of related diseases. Link to the MPI-NAT press release (in German)
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27.05.2022

Remote control of the heart and beyond

Authors Zimmermann WH Journal Science Citation Science. 2022 May 27;376(6596):917-918. Abstract A resorbable closed-loop sensor-actuator implant can temporarily control heart rate. DOI 10.1126/science.abq0605 Pubmed Link  
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26.05.2022

Excited state lifetime modulation in semiconductor nanocrystals for super-resolution imaging

Authors Ghosh S, Hollingsworth JA, Gallea JI, Majumder S, Enderlein J, Chizhik AI Journal Nanotechnology Citation Nanotechnology. 2022 Jun 15;33(36). Abstract We report on proof of principle measurements of a concept for a super-resolution imaging method that is based on excitation field density-dependent lifetime modulation of semiconductor nanocrystals. The prerequisite
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25.05.2022

Electrically Controlling and Optically Observing the Membrane Potential of Supported Lipid Bilayers

Authors Yudovich S, Marzouqe A, Kantorovitsch J, Teblum E, Chen T, Enderlein J, Miller EW, Weiss S Journal Biophysical Journal Citation Biophys J. 2022 May 25:S0006-3495(22)00430-1 Abstract Supported lipid bilayers are a well-developed model system for the study of membranes and their associated proteins, such as membrane channels, enzymes, and
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Dr. Lukas Cyganek, Department of Cardiology and Pneumology, Head of the Stem Cell Unit, University Medical Center Göttingen. Photo: umg/hzg

24.05.2022

Noonan syndrome: DFG funds research into new treatment options

The German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) is funding research into personalised treatment options for Noonan syndrome in the Stem Cell Unit at the University Medical Center Göttingen (UMG) with 467,580 euros. The team led by MBExC member Dr Lukas Cyganek will conduct research for three years on the topic
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