2021

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19.07.2021

Optical hearing!? Round table with Prof. Dr. Tobias Moser in “Lautstark, der Talk rund ums Hören”.

In the 19th episode of the series “Lautstark, der Talk rund ums Hören” of the German Cochlear Implant Society (Deutsche Cochlea Implantat Gesellschaft e.V.), Prof. Dr. Tobias Moser, speaker of the MBExC, explains vividly how optogenetics can restore lost hearing function. The round table is simultaneously translated into written text.
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16.07.2021

CaMKII inhibition has dual effects on spontaneous Ca2+ release and Ca2+ alternans in ventricular cardiomyocytes from mice with a gain-of-function RyR2 mutation

Authors Sadredini M, Haugsten Hansen M, Frisk M, Louch WE, Lehnart SE, Sjaastad I, Stokke MK Journal American Journal of Physiology. Heart and Circulatory Physiology Citation Am J Physiol Heart Circ Physiol. 2021 Jul 16. Abstract In conditions with abnormally increased activity of the cardiac ryanodine receptor (RyR2), Ca2+/calmodulin-dependent protein
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15.07.2021

Conditional Loss of BAF (mSWI/SNF) Scaffolding Subunits Affects Specification and Proliferation of Oligodendrocyte Precursors in Developing Mouse Forebrain

Authors Abbas E, Hassan MA, Sokpor G, Kiszka K, Pham L, Kerimoglu C,  Fischer A, Nguyen HP, Staiger JF, Tuoc  T Journal Frontiers in Cell and Developmental Biology Citation Front Cell Dev Biol. 2021 Jul 15;9:619538. Abstract Oligodendrocytes are responsible for axon myelination in the brain and spinal cord. Generation
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14.07.2021

Allosteric transcription stimulation by RNA polymerase II super elongation complex

Authors Chen Y, Vos SM, Dienemann C, Ninov M, Urlaub H, Cramer P Journal Molecular Cell Citation Molecular Cell (2021). In press. Abstract The super elongation complex (SEC) contains the positive transcription elongation factor b (P-TEFb) and the subcomplex ELL2-EAF1, which stimulates RNA polymerase II (RNA Pol II) elongation. Here,
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13.07.2021

Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery

Authors Walter C, Marada A, Suhm T, Ernsberger R, Muders V, Kücükköse C, Sánchez-Martín P, Hu Z, Aich A, Loroch S, Solari FA, Poveda-Huertes D, Schwierzok A, Pommerening H, Matic S, Brix J, Sickmann A, Kraft C, Dengjel J, Dennerlein S, Brummer T, Vögtle FN, Meisinger C Journal Nature Communications
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09.07.2021

Biallelic variants in PCDHGC4 cause a novel neurodevelopmental syndrome with progressive microcephaly, seizures, and joint anomalies

Authors Iqbal M, Maroofian R, Çavdarlı B, Riccardi F, Field M, Banka S, Bubshait DK, Li Y, Hertecant J, Baig SM, Dyment D, Efthymiou S, Abdullah U, Makhdoom EUH, Ali Z, Scherf de Almeida T, Molinari F, Mignon-Ravix C, Chabrol B, Antony J, Ades L, Pagnamenta AT, Jackson A, Douzgou
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09.07.2021

isoSTED microscopy with water-immersion lenses and background reduction

Authors Siegmund R, Werner F, Jakobs S, Geisler C, Egner A Journal Biophysical Journal Citation Biophys J. 2021 Jul 8:S0006-3495(21)00556-7. Abstract Fluorescence microscopy is an excellent tool to gain knowledge on cellular structures and biochemical processes. Stimulated emission depletion (STED) microscopy provides a resolution in the range of a few
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08.07.2021

Stefan Hell and Erwin Neher are Honorary Fellows of the IUPS

The International Union of Physiological Sciences (IUPS) has elected Stefan Hell and Erwin Neher from the Max Planck Institute for Biophysical Chemistry as Honorary Fellows. The MBExC members were honored for their groundbreaking research of great importance to the field of physiology. IUPS is a non-political and non-geographical scientific organization
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07.07.2021

Preclinical evidence for the therapeutic value of TBX5 normalization in arrhythmia control

Authors Rathjens FS, Blenkle A, Iyer LM, Renger A, Syeda F, Noack C, Jungmann A, Dewenter M, Toischer K, El-Armouche A, Müller OJ, Fabritz L, Zimmermann WH, Zelarayan LC, Zafeiriou MP Journal Cardiovascular Research Citation Cardiovasc Res. 2021 Jul 7;117(8):1908-1922. Abstract Aims  Arrhythmias and sudden cardiac death (SCD) occur commonly
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06.07.2021

EU-funded project IMAGEOMICS starts

The EU project “Imaging the proteome at the nanoscale” (IMAGEOMICS) will be funded within the “FET Open” program, which honors novel ideas for radically new technologies with a total amount of 3,7 Mio Euros. MBExC member Prof. Dr. Silvio Rizzoli from the University Medical Center Göttingen will coordinate the international
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