2020

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01.10.2020

Emerging Approaches for Restoration of Hearing and Vision

Authors Kleinlogel S, Vogl C, Jeschke M, Neef J, Moser T Journal Physiological Reviews Citation Physiol Rev. 2020 Oct 1;100(4):1467-1525. Abstract Impairments of vision and hearing are highly prevalent conditions limiting the quality of life and presenting a major socioeconomic burden. For a long time, retinal and cochlear disorders have
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21.09.2020

Ultrastructural Imaging of Activity-Dependent Synaptic Membrane-Trafficking Events in Cultured Brain Slices

Authors Imig C, López-Murcia FJ, Maus L, García-Plaza IH, Mortensen LS, Schwark M, Schwarze V, Angibaud J, Nägerl UV, Taschenberger H, Brose N, Cooper BH Journal Neuron Citation Neuron. 2020 Sep 21:S0896-6273(20)30704-2. Abstract Electron microscopy can resolve synapse ultrastructure with nanometer precision, but the capture of time-resolved, activity-dependent synaptic membrane-trafficking
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16.09.2020

Model-based reconstruction for simultaneous multi-slice T1 mapping using single-shot inversion-recovery radial FLASH

Authors Wang X, Rosenzweig S, Scholand N, Holme HCM, Uecker M Journal Magnetic Resonance in Medicine Citation Magn Reson Med. 2020 Sep 16. Abstract Purpose: To develop a single-shot multi-slice T1 mapping method by combing simultaneous multi-slice (SMS) excitations, single-shot inversion-recovery (IR) radial fast low-angle shot (FLASH), and a nonlinear
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16.09.2020

Seeded intervals and noise level estimation in change point detection: A discussion of Fryzlewicz (2020)

Authors Kovács S, Li H, Bühlmann P Journal Journal of the Korean Statistical Society Citation J. Korean Stat. Soc. (2020). Abstract In this discussion, we compare the choice of seeded intervals and that of random intervals for change point segmentation from practical, statistical and computational perspectives. Furthermore, we investigate a
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09.09.2020

3D analysis of the myenteric plexus of the human bowel by X-ray phase-contrast tomography – a future method?

Authors Peruzzi N, Veress B, Dahlin LB, Salditt T, Andersson M, Eckermann M, Frohn J, Robisch AL, Bech M, Ohlsson B Journal Scandinavian Journal of Gastroenterology Citation Scand J Gastroenterol. 2020 Oct;55(10):1261-1267. Abstract Objectives: Light microscopical analysis in two dimensions, combined with immunohistochemistry, is presently the gold standard to describe
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01.09.2020

14-3-3 binding creates a memory of kinase action by stabilizing the modified state of phospholamban

Authors Menzel J, Kownatzki-Danger D, Tokar S, Ballone A, Unthan-Fechner K, Kilisch M, Lenz C, Urlaub H, Mori M, Ottmann C, Shattock MJ, Lehnart SE, Schwappach B Journal Science Signaling Citation Sci Signal. 2020 Sep 1;13(647):eaaz1436. Abstract The cardiac membrane protein phospholamban (PLN) is targeted by protein kinase A (PKA)
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28.08.2020

Premature aging disorders: A clinical and genetic compendium

Authors Schnabel F, Kornak U, Wollnik B Journal Clinical Genetics Citation Clin Genet. 2020 Aug 28. Abstract Progeroid disorders make up a heterogeneous group of very rare hereditary diseases characterized by clinical signs that often mimic physiological aging in a premature manner. Apart from Hutchinson-Gilford progeria syndrome, one of the
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High power magnification of a neuronal network in a BENO. Axons are highlighted by staining of Neurofilament protein in green, glutamatergic neurons by staining of the Vesicular Glutamate Transporter protein in red and nuclei labelled in blue. The study by Zafeiriou et al. demonstrated for the first time that functional neuronal networks with properties of the human brain can be bioengineered from induced pluripotent stem cells at the macroscopic tissue scale. Network formation is key for normal brain function, including learning, and is compromised in disease such as epilepsia, dementia, or stroke. Figures from Zafeiriou et al. (2020) GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids. Nat Commun, 11, 3791.

28.08.2020

Generation of human brain organoids with the ability to learn

Stem cell technologies are revolutionizing the biomedical field. Scientists at the University Medical Center Göttingen (UMG) in collaboration with research partners of the Cluster of Excellence “Multiscale Bioimaging” (MBExC) and the German Center for Neurodegenerative Disease (DZNE) combined induced pluripotent stem cells (iPSC) and their deep knowledge in the bioengineering
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High power magnification of a neuronal network in a BENO. Axons are highlighted by staining of Neurofilament protein in green, glutamatergic neurons by staining of the Vesicular Glutamate Transporter protein in red and nuclei labelled in blue. The study by Zafeiriou et al. demonstrated for the first time that functional neuronal networks with properties of the human brain can be bioengineered from induced pluripotent stem cells at the macroscopic tissue scale. Network formation is key for normal brain function, including learning, and is compromised in disease such as epilepsia, dementia, or stroke. Figures from Zafeiriou et al. (2020) GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids. Nat Commun, 11, 3791.

28.08.2020

Generation of human brain organoids with the ability to learn

Stem cell technologies are revolutionizing the biomedical field. Scientists at the University Medical Center Göttingen (UMG) in collaboration with research partners of the Cluster of Excellence “Multiscale Bioimaging” (MBExC) and the German Center for Neurodegenerative Disease (DZNE) combined induced pluripotent stem cells (iPSC) and their deep knowledge in the bioengineering
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26.08.2020

Bioprospection of Natural Sources of Polyphenols with Therapeutic Potential for Redox-Related Diseases

Authors Menezes R, Foito A, Jardim C, Costa I, Garcia G, Rosado-Ramos R, Freitag S, Alexander CJ, Outeiro TF, Stewart D, Santos CN Journal Antioxidants Citation Antioxidants (Basel). 2020 Aug 26;9(9):E789. Abstract Plants are a reservoir of high-value molecules with underexplored biomedical applications. With the aim of identifying novel health-promoting
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