April

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30.04.2020

Wide-Field Fluorescence Lifetime Imaging of Single Molecules

Authors Oleksiievets N, Thiele JC, Weber A, Gregor I, Nevskyi O, Isbaner S, Tsukanov R, Enderlein J Journal Journal of Physical Chemistry A Citation J Phys Chem A. 2020 Apr 30;124(17):3494-3500. Abstract Fluorescence lifetime imaging (FLIM) has become an important microscopy technique in bioimaging. The two most important of its applications are lifetime-multiplexing for imaging many different structures in
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24.04.2020

A cross-linking mass spectrometry approach defines protein interactions in yeast mitochondria

Authors Linden A, Deckers M, Parfentev I, Pflanz R, Homberg B, Neumann P, Ficner R, Rehling P, Urlaub H Journal Molecular & Cellular Proteomics Citation Mol Cell Proteomics. 2020 Apr 24;mcp.RA120.002028. Abstract Protein cross-linking and the analysis of cross-linked peptides by mass spectrometry is currently receiving much attention. Not only
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24.04.2020

Staying in touch with society

Communicating scientific findings to the local, regional, national, and international public, and raising awareness about integrative research and topics of MBExC is of major importance for us and society. Here we engage in dialogue with the public promoting interest and confidence in science. In June 2019 the MBExC presented selected
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22.04.2020

A Transcriptome Analysis Identifies Potential Preventive and Therapeutic Approaches Towards COVID-19

Authors Islam MR, Fischer A Journal Preprints Citation Preprints 2020, 2020040399. Abstract The recent outbreak of Coronavirus Disease 2019 (COVID-19) is a major threat to human health and the global economy. In addition to the development of vaccines there is an urgent need for preventive and therapeutic strategies towards severe
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22.04.2020

Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function

Authors Dodonova SO, Zhu F, Dienemann C, Taipale J, Cramer P Journal Nature Citation Nature 580, 669–672 (2020). Abstract ‘Pioneer’ transcription factors are required for stem-cell pluripotency, cell differentiation and cell reprogramming1,2. Pioneer factors can bind nucleosomal DNA to enable gene expression from regions of the genome with closed chromatin.
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15.04.2020

One of the ERC Advanced Grants for Patrick Cramer

Every year, top researchers apply to the European Research Council (ERC) for funding. The highly remunerated ERC Advanced Grants are particularly sought after. Patrick Cramer, Max Planck Director and vice speaker of the MBExC in Göttingen, was successful for the third time – an exceptional achievement. The biochemist investigates how
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08.04.2020

Challenges to heart repair with pluripotent stem cell-derived cardiomyocytes

Authors Zimmermann WH Journal Trends in Cardiovascular Medicine Citation Trends Cardiovasc Med 2020 Apr 8;S1050-1738(20)30049-9 Abstract no abstract available DOI 10.1016/j.tcm.2020.03.006 Pubmed Link  
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07.04.2020

Towards the optical cochlear implant: optogenetic approaches for hearing restoration

Authors Dieter A, Keppeler D, Moser T Journal Cell Reports Citation EMBO Mol Med 2020 Apr 7;12(4):e11618. Abstract Cochlear implants (CIs) are considered the most successful neuroprosthesis as they enable speech comprehension in the majority of half a million CI users suffering from sensorineural hearing loss. By electrically stimulating the
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07.04.2020

Kinetics of Loop Closure in Disordered Proteins: Theory vs Simulations vs Experiments

Authors Satija R, Das A, Mühle S, Enderlein J, Makarov DE Journal Journal of Physical Chemistry B Citation J Phys Chem B. 2020 Apr 30;124(17):3482-3493. Abstract We study intrachain dynamics of intrinsically disordered proteins, as manifested by the time scales of loop formation, using atomistic simulations, experiment-parametrized coarse-grained models, and
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01.04.2020

Tissue engineered heart repair from preclinical models to first-in-patient studies

Authors Zimmermann WH Journal Current Opinion in Physiology Citation Current Opinion in Physiology 2020, 14:70–77. Abstract The lack of regenerative therapies for the treatment of degenerative diseases, such as heart failure, motivates the search for cell therapeutics. From a technical point of view, cell-based heart repair is approached from two
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